Antineoplastic, immunogenic and other effects of the tetrapeptide tuftsin: a natural macrophage activator.
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چکیده
منابع مشابه
Tuftsin-Bearing Liposomes as Antibiotic Carriers in Treatment of Macrophage Infections
Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg) that specifically binds monocytes, macrophages, and polymorphonuclear leukocytes and potentiates their natural killer activity against tumors and pathogens. The antimicrobial activity of this peptide is significantly increased by attaching at the C-terminus a fatty acyl residue through the ethylenediamine spacer arm. This activity is further augmented...
متن کاملTuftsin-bearing liposomes as antibiotic carriers in treatment of macrophage infections.
Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg) that specifically binds monocytes, macrophages, and polymorphonuclear leukocytes and potentiates their natural killer activity against tumors and pathogens. The antimicrobial activity of this peptide is significantly increased by attaching at the C-terminus a fatty acyl residue through the ethylenediamine spacer arm. This activity is further augmented...
متن کاملInteractions of tuftsin with bovine serum albumin.
Interactions of tuftsin (Thr-Lys-Pro-Arg) with bovine serum albumin (BSA) were analysed by fluorescence spectroscopy and circular dichroism. The data show that tuftsin interacts weakly with BSA, but this interaction is considerably enhanced by introducing an apolar substituent at the C-terminus of the tetrapeptide. It is suggested that strong binding of tuftsin to albumin in blood may enhance i...
متن کاملProtective effect of liposomal formulation of tuftsin (a naturally occurring tetrapeptide) against cyclophosphamide-induced genotoxicity and oxidative stress in mice.
Tuftsin, a naturally occurring tetrapeptide with a sequence Thr-Lys-Pro-Arg was evaluated for its in vivo protective effect against cyclophosphamide-induced genotoxicity and oxidative stress in Swiss albino mice. The anticancer drug cyclophosphamide (CP) was administered intra-peritonially to induce mutagenic effect. The drug treatment caused significant increase in chromosomal aberrations, for...
متن کاملThe effect of Tuftsin on the nitrous blue tetrazolium reduction of normal human polymorphonuclear leukocytes.
The influence of Tuftsin, the synthetic phagocytosis-stimulating tetrapeptide (L-threonyl-L-lysyl-L-prolyl-L-arginine), on the nitrous blue tetrazolium (NBT) reduction by human polymorphonuclear leukocytes was investigated. It was found that this substance increases the NBT reduction by approximately as much as endotoxin. Other tetrapeptides do not share this property. When Tuftsin analogs are ...
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ورودعنوان ژورنال:
- Annals of the New York Academy of Sciences
دوره 419 شماره
صفحات -
تاریخ انتشار 1983